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in vivo bioavailability studies of sumatriptan succinate

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In vivo bioavailability studies of sumatriptan succinate ...

In vivo bioavailability studies was also conducted in rabbits for optimized formulation using oral solution of sumatriptan succinate as standard. RESULTS: Bilayered buccal tablets (BBT) containing the mixture of Carbopol and HPMC K4M in the ratio 1:1 (T1) had the maximum percentage of in

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In vivo bioavailability studies of sumatriptan succinate ...

In vivo bioavailability studies was also conducted in rabbits for optimized formulation using oral solution of sumatriptan succinate as standard. Results Bilayered buccal tablets (BBT) containing the mixture of Carbopol and HPMC K4M in the ratio 1:1 (T1) had the maximum percentage of in

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In vivo bioavailability studies of Sumatriptan succinate ...

Sumatriptan succinate containing buccal patch displayed almost 1.73 folds and 2 folds higher Cmax and AUC, respectively, than plain drug solution. 1.93% of relative bioavailability was reported ...

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In vivo bioavailability studies of sumatriptan succinate ...

In vivo bioavailability studies was also conducted in rabbits for optimized formulation using oral solution of sumatriptan succinate as standard. Results:Bilayered buccal tablets (BBT) containing the mixture of Carbopol and HPMC K4M in the ratio 1:1 (T1) had the maximum percentage of in

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Shivanand K, Raju SA, Nizamuddin S, Jayakar B

In vivo bioavailability studies of sumatriptan succinate buccal tablets *1 Shivanand K, 2 Raju SA, 1 Nizamuddin S, 3 Jayakar B 1 Acharya and B M Reddy College of Pharmacy, Bangalore-560090, India.

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Preparation and in vivo evaluation of oral dissolving ...

2019-7-9  headache [10]. Sumatriptan succinate is the first member of a new class of antimigraine compounds that act as a specific and selective 5-hydroxytryptamine-1 receptor agonist [11]. The lower bioavailability of sumatriptan succinate is primarily because of presystemic first-pass metabolism and partly because of incomplete absorption [12].

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Enhanced pharmacological efficacy of sumatriptan

2018-11-1  In vivo bioavailability studies of sumatriptan succinate buccal tablets. Daru 19 (3), 224–230 (2011). CAS PubMed PubMed Central Google Scholar

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Fast-Dissolving Films of Sumatriptan Succinate:

2015-3-22  Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth.

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Buccal Mucoadhesive Tablets of Sumatriptan Succinate

2019-1-30  Sumatriptan Succinate mucoadhesive matrix tablets were formulated by direct compression method. The formulation composition of different batch is shown in table 1 . All the powders passed through 40 mesh sieve. The required quantity of Sumatriptan Succinate, various polymers and fillers

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QBD APPROACH IN FORMULATION AND EVALUATION

2019-12-10  Sumatriptan succinate is an antimigraine and pain inhibitory drug. Sumatriptan succinate has half‐life of 2.5 hrs. Its total bioavailability in the body is 06% due to first pass metabolism. Also Sumatriptan succinate is an acid sensitive that is readily reacts in the gastric environment thus reduces its oral bioavailability.

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Preparation and in vivo evaluation of oral dissolving ...

2019-7-9  headache [10]. Sumatriptan succinate is the first member of a new class of antimigraine compounds that act as a specific and selective 5-hydroxytryptamine-1 receptor agonist [11]. The lower bioavailability of sumatriptan succinate is primarily because of presystemic first-pass metabolism and partly because of incomplete absorption [12].

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Fast-Dissolving Films of Sumatriptan Succinate:

Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth.

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Development and Evaluation of in-situ Nasal Gel ...

2019-12-27  Background: Sumatriptan succinate (SUT) is a potent drug used for relieving or ending migraine and cluster headaches. SUT bioavailability is low (15%) when it is taken orally owing to its gastric breakdown and bloodstream before reaching the target arteries.

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Enhanced Iontophoretic Delivery of Sumatriptan

2014-7-24  Sumatriptan succinate (SS) is 3-[2-(dimethylamino) ethyl]-N-methyl-indole-5methanesulfonamide succinate. The free base has a molecular weight of 295.4 and a pKa of 9.63. The succinate salt is freely soluble in water and phosphate buffer, and its molecular weight is 413.5.1 It is a selective serotonin agonist used to control migraine.

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Buccal Mucoadhesive Tablets of Sumatriptan Succinate

2019-1-30  Sumatriptan Succinate mucoadhesive matrix tablets were formulated by direct compression method. The formulation composition of different batch is shown in table 1 . All the powders passed through 40 mesh sieve. The required quantity of Sumatriptan Succinate, various polymers and fillers

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Fast-Dissolving Films of Sumatriptan Succinate:

Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth. Films were prepared by ...

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Brain targeted delivery of sumatriptan succinate

2020-10-27  Sumatriptan succinate has a rapid but incomplete absorption from the gastrointestinal (GI) tract and underlies the first-pass metabolism by hepatic monoamine oxidase (MAO) which produces two inactive metabolites, N-oxide and indole acetic acid analogs. therefore, It has a low oral bioavailability

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CENTER FOR DRUG EVALUATION AND RESEARCH

2011-5-11  (Sumatriptan Succinate) autoinjector is a pre-filled, fully assembled single-use disposable auto-injector product containing 6 mg of sumatriptan (base) as the succinate salt delivered in a 0.5 mL subcutaneous dose. This product is intended for the acute treatment of migraine attacks with or without aura and the acute treatment of cluster

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FORMULATION AND EVALUATION OF PRONIOSOME

2019-2-1  Sumatriptan succinate. Sumatriptan is a 5-hydroxy tryptamine 1D (5-HT1D)-receptor agonist, it was the first triptan available to use in the treatment of migraine. Sumatriptan is metabolized primarily by monoamine oxidase A and excreted in the urine and bile 6. Sumatriptan seems to act selectively on blood vessels located within the

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Research Article

2019-11-11  In vivo bioavailability studies In vivo bioavailability studies were conducted in healthy male rabbits weighing 2-2.5 kg. Twelve rabbits were divided into two groups of six each and were fasted for 24 hours9-11. One group was fed with Oral tablet preparation, the

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Fast-Dissolving Films of Sumatriptan Succinate:

Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth.

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Optimization of Sumatriptan Succinate Transdermal

2019-7-13  Purpose: Sumatriptan succinate is a BCS class III drug. Oral administration of drug suffers from poor bioavailability problem due to pre-systemic metabolism. Bioavailability for oral route is 15%, for nasal route is 17% and for parenteral route is 97%.

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Enhanced Iontophoretic Delivery of Sumatriptan

2014-7-24  Sumatriptan succinate (SS) is 3-[2-(dimethylamino) ethyl]-N-methyl-indole-5methanesulfonamide succinate. The free base has a molecular weight of 295.4 and a pKa of 9.63. The succinate salt is freely soluble in water and phosphate buffer, and its molecular weight is 413.5.1 It is a selective serotonin agonist used to control migraine.

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FORMULATION AND EVALUATION OF BILAYER BUCCAL

2020-12-29  : Mucoadhesive bilayered buccal tablet of sumatriptan succinate may have enhanced bioavailability. A combination of polymer HPMC K15: HPMC K100LV in the ratio of 1:3 shows good mucoadhesive strength, ex-vivo drug release, and good mucoadhesive time. Keywords: Bilayer buccal tablet, Sumatriptan succinate, mucoadhesive strength, HPMC K100LV.

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Fast-Dissolving Films of Sumatriptan Succinate:

Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth. Films were prepared by ...

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[Full text] Development and Evaluation of in-situ Nasal ...

Background: Sumatriptan succinate (SUT) is a potent drug used for relieving or ending migraine and cluster headaches. SUT bioavailability is low (15%) when it is taken orally owing to its gastric breakdown and bloodstream before reaching the target arteries.

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DailyMed - SUMATRIPTAN SUCCINATE tablet

Sumatriptan succinate tablets should not be administered to patients with hemiplegic or basilar migraine. Sumatriptan succinate tablets and any ergotamine-containing or ergot-type medication (like dihydroergotamine or methysergide) should not be used within 24 hours of each other, nor should sumatriptan and another 5-HT 1 agonist.

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FORMULATION AND EVALUATION OF NOVEL SELF

INTRODUCTION: Sumatriptan succinate (STS) is 1-[3-(2-dimethylaminoethyl)-1 H-indol-5-yl]-N-methyl-methane sulfonamide succinate.It is a 5-HT1 receptor agonist used in the treatment of migraine 1.STS is a BCS class III drug that having oral bioavailability of 15-17% because of extensive presystemic metabolism 2, 3.. Solid dispersion, use of complexing agents, micronization, lyophilization ...

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FORMULATION AND EVALUATION OF FAST

ABSTRACT: In the present study an attempt has been made to prepare fast dissolving tablets of Sumatriptan Succinate to improve dissolution rate of the drug in oral cavity hence better patient’s compliance effective therapy.Sumatriptan Succinate is a 5-HT1D (5-hydroxy tryptamine 1D) receptor agonist, used in the treatment of migraine and cluster headache.

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DailyMed - SUMATRIPTAN SUCCINATE tablet, film

2018-7-16  Sumatriptan succinate, USP is a white to off-white powder that is readily soluble in water and in saline. Each sumatriptan tablet for oral administration contains 35, 70, or 140 mg of sumatriptan succinate equivalent to 25, 50, or 100 mg of sumatriptan, respectively.

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